Endocrine Abstracts

Cellular Ca2+ signals have been proposed to activate signal for hormone secretion. In pancreatic β cell which produce insulin, Ca2+ signals have been known contributing insulin secretion. Prior to conduct this study, we confirmed Calbindin-D9k (CaBP-9k) which responsible for regulation of the distribution of free calcium in the cytoplasm. We confirmed Insulin-secreting β cell express CaBP-9k and assumed that CaBP-9k play a certain role in β...

Calcium is important for physiological functioning in many tissues and is essential in mucus secretion. Previously reported, Mucin secretion is regulated predominantly by cytosolic calcium-dependent pathways. Cytosolic of calcium are regulated by calcium channels such as TRPV6, NCX1, and PMCA1. A549 cell line was treated with 10−8 M dexamethasone (DEX) and 10−6 M RU486. Subsequently, the expression of TRPV6, NCX1, and PMCA1 in A549 cell line w...

Calbindin-D9k (CaBP-9k), one of the major calcium-binding and calcium-buffering proteins, is important in the physiological functioning of organs. The neuroanatomical localization of CaBP-9k in the rodent brain has not been reported; thus, this study investigated the neuroanatomical distribution of CaBP-9k and the regulation of CaBP-9k expression on steroid hormones in the immature rat brain. To confirm the influence of steroid hormones on CaBP-9k expression, immatu...

NCKX3 (Sodium/potassium/calcium exchanger 3), a novel member of the family of K+-dependent Na+/Ca2+ exchangers, is an important component of intracellular Ca2+ homeostasis. Ca2+ homeostasis has been extensively studied in various cell systems. Dysregulation of Ca2+ homeostasis can induce the excitotoxic and neurodegeneration in central nervous system. NCKX3 gene is highly expressed in thalamic nuclei, in hippoca...

Introduction: 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) has been associated with several human metabolic disorders and is converted from inactive 11-keto form to glucocorticoid (GC or cortisol). GC overproduction or hypercortisolism is a major diagnostic factor of Cushing syndrome and Anorexia. GCs regulate carbohydrate, fat, and protein metabolism.Materials and methods: Previously we established porcine fibroblasts overexpressing 11&#...

It has been proposed that cellular Ca2+ signals activate hormone secretion. In pancreatic β cells, which produce insulin, Ca2+ signals have been known to contribute to insulin secretion. In previous study, demonstrated that endocrine disrupting chemicals (EDCs) such as bisphenol A (BPA) and Octylphenol (OP) could cause increase in insulin level and insulin transcription factors. But in regulations of plasma glucose level were not decreased as much as...

Introduction: Phthalates are chemicals used to improve the plasticity of industrial polymers and used in commercial products such as toys, paints, packaging materials, medicals devices and personal care items. Phthalates, endocrine disrupting chemicals, have been documented to cause adverse effects to the human health such as breast cancer in female, reduced uroogenital distance and changed the expression of steroidogenesis and folliculogenessis. In this study, we investigated...

Miscarriage is a very common occurrence in humans, in which blastocyst implantation failure in naturally-occurring and assisted human reproduction occurs in up to 2/3 of all cases. Calcium (Ca2+) has been showed to involve in many cellular signal transduction pathways as well as regulation of cell adhesion, which is necessary for the physiology process of endometrial epithelial cell transformation and stromal cell decidualization during embryo implantation. Previous...

Endocrine-disrupting chemicals (EDCs) are structures similar to steroids hormones which can interfere with hormone synthesis and normal physiological functions of male and female reproductive organs. EDCs tend to bind to steroid hormone receptors. Sex steroid hormones influence calcium signaling of the cardiac muscle in early embryo-development. Progesterone (P4) has been reported to affect both blood pressure and other aspects of the cardiovascular system. To confirm the affe...